Oxidized Cholesterol What It Is & How To Lower It

is oxidized cholesterol a real thing

Hydrogen peroxide and superoxide anions are produced by xanthine oxidases (XO) with the use of molecular oxygen as an electron acceptor. Xanthine oxidases can be found in blood plasma and within the population of endothelial cells. Also, elevated levels of XO were observed in atherosclerotic plaques (Martin et al., 2004). Xanthine oxidase inhibitors were shown to reduce the atherogenesis process in apoE-/- mice.

Smaller LDL particles are more likely to become oxidized, making them more detrimental to your health. As LDLs encounter free radicals, the two compounds combine through a chemical process known as oxidation and form oxidized LDL cholesterol. Oxidized LDL, or oxLDL, is a type of low-density lipoprotein (known as LDL cholesterol) that has become damaged by a chemical reaction with harmful molecules known as free radicals. Multiple LDL modifications occurring in the blood and vessel wall. Pieces of evidence that support the theory of oxidative modification.

P22phox and a Nox homologue, two membranes bound subunits, and also few cytosolic regulatory subunits form an NADPH oxidase complex (Panday et al., 2015). Nox was first identified to be expressed in the membrane of professional phagocytic cells, such as macrophages, neutrophils, monocytes, click here for info tissue dendritic cells, and mast cells. These cells produce many ROS to deal with pathogens (Cross and Segal, 2004). Then, NADPH oxidases were also found in other nonphagocytic cell types, among which there are smooth muscle cells (SMCs) and endothelial cells (ECs) (Pendyala et al., 2009).

This is potential evidence of the LOX-1 involvement in foam cell formation and activation of the endothelium. Experiments on mice have shown that LOX-1 can also play an important role in the inflammatory response and lipid deposition in heart vessels (Xu et al., 2013). Oxidative stress manifests page itself in excessive ROS generation and oxidation of LDL particles. The emergence of oxLDL is crucial for the progression of CVD linked to atherosclerosis. Induction of intracellular cholesterol accumulation was assessed to estimate the atherogenic properties of a lipoprotein particle.

Oxidized LDL can build up on the artery walls due to eating certain foods high in trans fats. Smoking tobacco products is also linked to high levels of oxidized LDL. Despite the significant role of oxidized LDL in atherogenesis, the understanding of the disease initiation and development progresses, and a new theory was formulated. It was shown that there are multiple modifications of LDL that allow particles to get the atherogenic properties, and the conception of multiple modifications was suggested. Moreover, traditional attitudes have been changed completely due to the recent findings concerning the event sequence in the atherosclerosis initiation. OxLDL was demonstrated to be involved in the foam cell formation and stimulation of the immune response.

is oxidized cholesterol a real thing

Two different types of tart cherries significantly reduced the cholesterol oxidation, but meat with a cherry on top seems a little out of place. Here’s the amount of oxidized cholesterol in a plain pork chop, significantly reduced by adding onion or garlic though, interestingly, in chicken, cholesterol oxidation was helped internet by sage, but not garlic. MiRNAs represent a group of small non-coding RNAs that bind their target mRNA and thus downregulate gene expression. This regulation mechanism is important for the development of atherosclerosis. Importantly, OxLDL was found to participate in microRNAs regulation (Feinberg and Moore, 2016).

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top