Oxidized Cholesterol: Definition, Effects, Diet Sources

what causes oxidized cholesterol

Plaque buildup can partially or completely block blood flow within an artery. The cholesterol that dangerously builds up on artery walls is oxidized. Gaining entrance into the endothelium, LDL gets oxidatively modified by ROS. With high cholesterol, you can develop fatty deposits in your blood vessels. Eventually, these deposits grow, making it difficult for enough blood to flow through your arteries.

If your doctor suspects higher levels of cholesterol in your body, they may recommend a routine blood test called a lipid profile. This profile will reveal the HDL, LDL, and triglyceride levels in your body. This can be understood with the help of a coronary artery calcium score CT scan. Yes, statins are medications that are made to lower the unhealthy (LDL) cholesterol levels in the body. They reduce the amount of cholesterol made by the liver and also assist the liver to remove the cholesterol that is already present in the blood.

what causes oxidized cholesterol

In laypeople’s terms, this is the hardening of the arteries which can decrease the blood flow in them increasing the risk of heart attack or stroke. The immune system can also mistake this oxidized type of cholesterol for bacteria. It will try to fight the bacteria page that can cause inflammation within the arterial walls. This efflux is the primary line of defence to protect against the progression of macrophage to foam cells. Further, antioxidants scavenge ROS combating atherosclerosis in the initiation period [34].

You’ve probably heard that too much saturated fat can lead to high cholesterol and eventually heart disease. LDL cholesterol molecules are not all the same size, and some are larger than others. Smaller LDL particles are more likely to become oxidized, making them more detrimental to your health. OxLDL measures the damage to the ApoB subunit on LDL cholesterol. This oxidative damage of LDL cholesterol is one of the first steps in the pathogenesis of atherosclerosis.

It belongs to a heterogeneous group of particles having a mass of about 3000 kDa with a diameter of 220 nm [36]. Research has shown that in patients with elevated oxidized cholesterol levels there is a significant increase in cardiac events. Upon that reaction, the LDLs become damaged, which triggers inflammation and attracts immune cells (white blood cells called macrophages). These white blood cells engulf the damaged learn more here LDLs, which creates a sticky aggregate complex that can attach easily to artery walls and form the basis of plaque. It’s the same with ground meat it’s just so much more exposed. Although levels in raw meats are usually low, concentrations tend to increase dramatically after exposure to pro-oxidation agents, such as light. What are you supposed to do, crawl inside the pig and eat the bacon from the inside?

ApoB in this context determines the generation and propagation of LDL oxidation. Additionally, the elevated temperature used while preparing meals increases the oxidation of cholesterol [42]. Nonetheless, oxysterols coming from the dietary sources into the bloodstream read what he said may implicate a fundamental role in the progression of this disease. Thereby, one cannot conclude the root embarking such progression and advanced studies need to be done. Schematic representation of HDL countering major atherosclerotic stages.

A plethora of research suggests that all these phenomena are more or less equally indispensable factors in the progression of atherosclerosis [71]. A lipid profile also typically measures triglycerides, a type of fat in the blood. Having a high triglyceride level also can increase your risk of heart disease.

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