Hypothyroidism Genetics: Causes, Inheritance, Risk

is hypothyroid genetic

Hashimoto’s disease is classified as an autoimmune disorder, one of a large group of conditions that occur when the immune system attacks the body’s own tissues and organs. In people with Hashimoto’s disease, white blood cells called lymphocytes accumulate abnormally in the thyroid, which can damage it. The lymphocytes make immune system proteins called antibodies that attack and destroy thyroid cells.

Understanding your familial risk can help you and your doctor create a plan to monitor thyroid function as you grow older. Take steps toward getting a diagnosis by working with your doctor, finding the right specialists, additional reading and coordinating medical care. Due to the downward trend in respiratory viruses in Maryland, masking is no longer required but remains strongly recommended in Johns Hopkins Medicine clinical locations in Maryland.

Affected women can have heavy or irregular menstrual periods and difficulty conceiving a child (impaired fertility). Difficulty concentrating and depression can also be signs of a shortage of thyroid hormones. Hashimoto’s disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions.

(If you’ve been avoiding soy or cauliflower to decrease your risk that’s just a myth.) But according to endocrinologist Christian Nasr, MD, many thyroid diseases do run in families. Though your hypothyroidism may be linked to your genes, this doesn’t mean that you are destined to or stuck with poor thyroid health for life. For example, low-carb [35], gluten-free [36], and dairy-free diets [37] have been shown to influence thyroid lab markers and antibodies. Pesticides and herbicides are known to negatively impact the thyroid and other endocrine organs [17, 38, 39, 40]. And foods high in iodine or iodine supplements have been shown to heavily influence the development of hypothyroidism [41, 42, 43]. Environmental triggers that influence thyroid genes and health include things like your iodine status [16], toxin exposure [17], or specific foods [18].

Over time, you may need checkups so that your health care provider can monitor your condition and medicine. An autoimmune disorder is an illness caused read what he said by the immune system attacking healthy tissues. In Hashimoto’s disease, immune-system cells lead to the death of the thyroid’s hormone-producing cells.

is hypothyroid genetic

According to a 2017 review, environmental factors account for approximately 20% of autoimmune hypothyroidism causes. A 2018 study, for example, found an inherited genetic mutation could alter how the body metabolizes thyroid hormone. For people living with this genetic variant, traditional treatments with the medication levothyroxine might not be as effective. Some genetics passed down from your parents look at this may even affect how well you respond to thyroid hormone replacement therapy in hypothyroidism. Hypothyroidism is sometimes linked to environmental factors like exposure to tobacco smoke and certain viruses, but it can also have underlying genetic influences. Hypothyroidism, also referred to as underactive thyroid, is a condition caused when your thyroid gland doesn’t produce enough hormones.

Thyroid hormones, particularly thyroxine (T4) and triiodothyronine (T3), are important regulators of your metabolism. The good news is you can positively influence your thyroid health by being mindful of your food and environmental toxin exposures and by attending to your gut health. Newborns are screened for congenital hypothyroidism soon after birth with a blood test, as a lack of treatment can cause severe developmental delays. Hashimoto’s disease (autoimmune hypothyroidism) is thought to be caused by a combination of inherited genes and environmental triggers [5, 6]. According to the American Thyroid Association, the most common type of hypothyroidism (in the US) is autoimmune thyroiditis, also called Hashimoto’s thyroiditis. The estimated prevalence of Hashimoto’s disease is between 1% and 2% in the United States, and women are 10 times more likely to have it than men [1].

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