Semaglutide, Also Known As Ozempic, For Weight Loss What You Need To Know

best diabetes drug for weight loss

Wegovy can have quite substantial effects about one in three people who take the drug lose 20% of their body weight, or 46 pounds on average. The active ingredient in Ozempic is semaglutide, which copies the glucagon-like peptide-1 (GLP-1) hormone. This helps the body produce more insulin and signals a feeling of fullness in the brain. Ozempic was first approved by the FDA in late 2017, and has since made headlines both for its intended use treating type 2 diabetes and for its off-label weight loss use, particularly among celebrities.

best diabetes drug for weight loss

For example, a 2021 clinical trial found that using 2.4 mg of semaglutide once per week in combination with diet and exercise had an association with significant, sustained weight loss. By week 68, participants in the semaglutide group had lost 14.9% of their starting body weight much higher than the 2.4% loss in the placebo group. These are both FDA-approved treatments for chronic weight management that the advantage come in once-weekly, pre-filled single-dose subcutaneous injection pens. Similarly to semaglutide, tirzepatide can help reduce a person’s food intake, which explains the drug’s ability to help people lose weight. Healthcare professionals will review medical conditions, medical and family history, health concerns, and other factors to consider appropriate candidates for diabetes medication for weight loss.

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If you have diabetes and already take a different medication, talk to your physician about acceptable (and safe) combinations of diabetes medication. One role of GLP-1 is to prompt look at more info the body to produce more insulin, which reduces blood sugar (glucose). For that reason, health care providers have used semaglutide for more than 15 years to treat Type 2 diabetes.

Low blood sugar levels (hypoglycemia) are a more serious risk linked to the GLP-1 class of drugs. But the risk of low blood sugar levels often only goes up if you’re also taking another drug known to lower blood sugar at the same time, such as sulfonylureas or insulin. Weight loss can vary depending on which GLP-1 drug you use and your dose.

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The United States Food and Drug Administration (FDA) has assigned Mounjaro a Fast Track designation for this use. There are several effective therapeutic options for weight loss in the GLP-1 agonist drug class. The best diabetes drug for weight loss is the one that works best for you, with the least amount of side effects. To determine which, if any, diabetes drug is best for you, speak with your healthcare provider. The chart below outlines the most common GLP-1 agonists (including Mounjaro) that are prescribed off-label for weight loss.

All but Rybelsus are injectable drugs administered subcutaneously (under the skin) of the stomach, upper arm, or thigh with a pen injector device. Although most are injected, they are not to be confused with insulin. Ozempic and Mounjaro are most frequently in the news, in high demand (leading to shortages), the advantage and even viral on social media, but any medication in this drug class may cause appetite and weight loss. There’s a class of type 2 diabetes drugs that not only improves blood sugar control but may also lead to weight loss. This class of drugs is commonly called glucagon-like peptide 1 (GLP-1) agonists.

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Gastrointestinal issues are the most common complaint among people just starting semaglutide. But you may be able to reduce the side effects by beginning on a lower dose and then slowly increasing the amount you take. Others aren’t sure side effects deter individuals so drastically, however.

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